The son of the famous doctor Gu Feng in Qingyuantang pharmacy was accidentally drowned and Gu Feng’s mother blamed his death on their butler, Fang Cheng. Fang Cheng felt grudged, as his bastard Qiang Wei with his mistress named He Xiu has nowhere to foster her. He secretly substituted his daughter for Gu Feng’s daughter Ren Dong who was once fostered elsewhere. Qiang Wei was brought to Gu family and raised up in a well-off environment, while Ren Dong was raised by He Xiu in a poor family. After they grew up, Ren Dong accidentally got a job in Qingyuantang pharmacy and met with Han Chong, who suffered many hardships in his life. Her optimistic nature and medical talent had soon made her popular in the pharmacy.